Succinylcholine resistance

Increased plasma cholinesterase activity and succinylcholine resistance: a genetic variant.

A defasciculating dose of d-tubocurarine causes resistance to succinylcholine.

Forty-four patients, ASA physical status I or II, undergoing thiamylal, fentanyl, N2O/O2 anaesthesia were studied to determine the dose-response to succinylcholine (Sch) without prior defasciculation (24 pt - Group 1), or three minutes following d-tubocurarine (dTC), 0.043 mg.kg-1 (20 pt - Group 2). The individual log dose-logit response curve for each patient was determined using a cumulative ...

Asystole after alfentanil- succinylcholine

To the Editor: Alfentanil is a new narcotic capable of blunting intraoperalive haemodynamic responses while allowing for return of spontaneous ventilation and consciousness after short surgical procedures. We have recently noted reports of severe bradycardia with the use of alfentanil combined with succinylcholine, t,2 We also present such a case. A 76-year-old 45 kg woman was scheduled for rem...

Succinylcholine-associated postoperative myalgia.

The subject of postoperative myalgia associated with the use of succinylcholine is reviewed. We discuss the mechanisms of succinylcholine-induced myalgia and the techniques available to prevent and treat the myalgia. In situations where patients are at risk of developing myalgia and succinylcholine is the neuromuscular blocker of choice, the use of a combination of techniques may prove to be a ...

Succinylcholine hyperkalemia after burns.

To the Editor-The appropriate review, "Anesthesia for Major Thermal Injury," overstates the contraindication to succinylcholine on pages 754 (". . . succinylcholine . . . >24 h after burn injury is unsafe") and 755 (". . . safe only within 24 h of a burn").' The safe period for burn patients is 6-7 days after a burn injury, whereas that for denervation is 4 days. Studies beginning 6 days after ...